Version 5.4
Mus musculus Gene: Cblc
Summary
InnateDB Gene IDBG-152552.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cblc
Gene Name Casitas B-lineage lymphoma c
Synonyms 2310076I21Rik; 2310079L19Rik; Cbl3
Species Mus musculus
Ensembl Gene ENSMUSG00000040525
Encoded Proteins
IDBP-152554
Casitas B-lineage lymphoma c
IDBP-264512
Casitas B-lineage lymphoma c
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142273:
This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19778881-19796809
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000043822 ENSMUSP00000039955
ENSMUST00000108449 ENSMUSP00000104088
ENSMUST00000125050
ENSMUST00000148416
ENSMUST00000145755
ENSMUST00000131276
ENSMUST00000131602
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein transferase activity
GO:0004871 signal transducer activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0017124 SH3 domain binding
GO:0046872 metal ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007166 cell surface receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0016567 protein ubiquitination
GO:0023051 regulation of signaling
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407 negative regulation of MAP kinase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000142273
View Gene Order
ENSBTAG00000009494
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04012
ErbB signaling pathway pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04630
Jak-STAT signaling pathway pathway
mmu04910
Insulin signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
mmu05220
Chronic myeloid leukemia pathway
mmu04144
Endocytosis pathway
mmu05200
Pathways in cancer pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04012
ErbB signaling pathway pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04910
Insulin signaling pathway pathway
hsa04660
T cell receptor signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa05220
Chronic myeloid leukemia pathway
hsa04144
Endocytosis pathway
hsa05200
Pathways in cancer pathway
hsa05100
Bacterial invasion of epithelial cells pathway
INOH
INOH website
GPCR Adenosine A2A receptor signaling pathway pathway
INOH website
GPCR signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.81698
RefSeq NM_001161844 NM_023224
OMIM
CCDS CCDS39804 CCDS52064
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca