InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acsl1

Summary

InnateDB Gene

IDBG-153894.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl1

Gene Name

acyl-CoA synthetase long-chain family member 1

Synonyms

Acas; Acas1; Acs; Facl2; FACS; LACS1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000018796

Encoded Proteins

IDBP-153896

acyl-CoA synthetase long-chain family member 1

IDBP-260410

acyl-CoA synthetase long-chain family member 1

IDBP-260412

acyl-CoA synthetase long-chain family member 1

IDBP-541472

acyl-CoA synthetase long-chain family member 1

IDBP-541692

acyl-CoA synthetase long-chain family member 1

IDBP-538496

acyl-CoA synthetase long-chain family member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:46471041-46536051

Strand

Forward strand

Band

B1.1

Transcripts

ENSMUST00000034046	ENSMUSP00000034046
ENSMUST00000110372	ENSMUSP00000106001
ENSMUST00000110371	ENSMUSP00000106000
ENSMUST00000128746
ENSMUST00000135955	ENSMUSP00000117546
ENSMUST00000130563	ENSMUSP00000114473
ENSMUST00000133161
ENSMUST00000152423	ENSMUSP00000118845

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0010033	response to organic substance
GO:0014070	response to organic cyclic compound
GO:0015908	fatty acid transport
GO:0033211	adiponectin-activated signaling pathway
GO:0034201	response to oleic acid
GO:0042178	xenobiotic catabolic process
GO:0042493	response to drug
GO:0044539	long-chain fatty acid import
GO:0071902	positive regulation of protein serine/threonine kinase activity

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane