Version 5.4
Bos taurus Gene: METTL3
Summary
InnateDB Gene IDBG-645993.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METTL3
Gene Name N6-adenosine-methyltransferase 70 kDa subunit
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015148
Encoded Proteins
IDBP-698757
N6-adenosine-methyltransferase 70 kDa subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165819:
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:25716677-25731504
Strand Forward strand
Band
Transcripts
ENSBTAT00000020151 ENSBTAP00000020151
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016422 mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
Biological Process
GO:0001510 RNA methylation
GO:0006139 nucleobase-containing compound metabolic process
GO:0006397 mRNA processing
GO:0007623 circadian rhythm
GO:0019827 stem cell maintenance
GO:0061157 mRNA destabilization
GO:0080009 mRNA methylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0036396 MIS complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000165819
View Gene Order
ENSMUSG00000022160
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_71
Gene Expression pathway
REACT_233572
Gene Expression pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F1MX80
UniProt Splice Variant
Entrez Gene 540339
UniGene Bt.13303
RefSeq NM_001102238
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028311
GenPept
RNA Seq Atlas 540339

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca