InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: NRP2

Summary

InnateDB Gene

IDBG-643390.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRP2

Gene Name

neuropilin-2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000011971

Encoded Proteins

IDBP-695953

neuropilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118257:
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:94455658-94573687

Strand

Forward strand

Band

Transcripts

ENSBTAT00000015885

ENSBTAP00000015885

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001755	neural crest cell migration
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007507	heart development
GO:0021675	nerve development
GO:0021828	gonadotrophin-releasing hormone neuronal migration to the hypothalamus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048846	axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0061549	sympathetic ganglion development
GO:0097490	sympathetic neuron projection extension
GO:0097491	sympathetic neuron projection guidance
GO:1902285	semaphorin-plexin signaling pathway involved in neuron projection guidance