Version 5.4
Mus musculus Gene: Mgat1
Summary
InnateDB Gene IDBG-166792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgat1
Gene Name mannoside acetylglucosaminyltransferase 1
Synonyms Mgat-1
Species Mus musculus
Ensembl Gene ENSMUSG00000020346
Encoded Proteins
IDBP-166794
mannoside acetylglucosaminyltransferase 1
IDBP-166796
mannoside acetylglucosaminyltransferase 1
IDBP-262914
mannoside acetylglucosaminyltransferase 1
IDBP-535920
mannoside acetylglucosaminyltransferase 1
IDBP-621760
mannoside acetylglucosaminyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131446:
There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:49244191-49263030
Strand Forward strand
Band B1.2
Transcripts
ENSMUST00000081794 ENSMUSP00000080484
ENSMUST00000101293 ENSMUSP00000098851
ENSMUST00000109194 ENSMUSP00000104817
ENSMUST00000135489
ENSMUST00000152451
ENSMUST00000156607
ENSMUST00000155806
ENSMUST00000148962
ENSMUST00000149406
ENSMUST00000129541
ENSMUST00000129588 ENSMUSP00000114965
ENSMUST00000135314
ENSMUST00000167400 ENSMUSP00000126303
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
GO:0008375 acetylglucosaminyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006049 UDP-N-acetylglucosamine catabolic process
GO:0006486 protein glycosylation
Cellular Component
GO:0000139 Golgi membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131446
View Gene Order
ENSBTAG00000001546
Not yet available
Pathways
NETPATH
REACTOME
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
REACT_198544
N-glycan trimming and elongation in the cis-Golgi pathway
KEGG
mmu00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25210
N-glycan trimming and elongation in the cis-Golgi pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.196933
RefSeq NM_001110148 NM_001110149 NM_001110150 NM_010794 XM_006532397 XM_006532398 XM_006532399 XM_006532400 XM_006532401
OMIM
CCDS CCDS24602
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca