Version 5.4
Mus musculus Gene: H2-Ke2
Summary
InnateDB Gene IDBG-168440.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol H2-Ke2
Gene Name H2-K region expressed gene 2
Synonyms H-2Ke2; H2-Ke2; Ke-2
Species Mus musculus
Ensembl Gene ENSMUSG00000024309
Encoded Proteins
IDBP-168442
H2-K region expressed gene 2
IDBP-626762
H2-K region expressed gene 2
IDBP-789488
prefoldin subunit 6
IDBP-626764
H2-K region expressed gene 2
IDBP-712880
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204220:
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:33938821-33940343
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000025163 ENSMUSP00000025163
ENSMUST00000174048 ENSMUSP00000133656
ENSMUST00000173363 ENSMUSP00000138662
ENSMUST00000174426 ENSMUSP00000134069
ENSMUST00000173678
ENSMUST00000179418 ENSMUSP00000137072
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
GO:0051087 chaperone binding
Biological Process
GO:0006457 protein folding
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0005634 nucleus
GO:0016272 prefoldin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000204220
View Gene Order
ENSBTAG00000010723
Not yet available
Pathways
NETPATH
REACTOME
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_247926
Metabolism of proteins pathway
REACT_260833
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_245534
Protein folding pathway
REACT_245663
Prefoldin mediated transfer of substrate to CCT/TriC pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16936
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
REACT_17029
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_223239
Prefoldin mediated transfer of substrate to CCT/TriC pathway
REACT_203284
Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding pathway
REACT_219091
Chaperonin-mediated protein folding pathway
REACT_213782
Metabolism of proteins pathway
REACT_215927
Protein folding pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001185182 NM_010385
OMIM
CCDS CCDS28636
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca