Version 5.4
Bos taurus Gene: BT.56893
Summary
InnateDB Gene IDBG-639763.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.56893
Gene Name activation-induced cytidine deaminase
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000018849
Encoded Proteins
IDBP-691950
activation-induced cytidine deaminase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24244169
[Homo sapiens] Kaposi's sarcoma-associated herpesvirus (KSHV) infection results in upregulation of AICDA in primary human tonsillar B cells. Two KSHV miRNAs, K12-11 and K12-5 interact with the 3â?²UTR of AICDA to translationally repress its expression.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111732:
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:101686492-101690821
Strand Forward strand
Band
Transcripts
ENSBTAT00000025096 ENSBTAP00000025096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 66 interaction(s) predicted by orthology.
Predicted by orthology
Total 66 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004126 cytidine deaminase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
Biological Process
GO:0009972 cytidine deamination
GO:0016445 somatic diversification of immunoglobulins
GO:0016446 somatic hypermutation of immunoglobulin genes
GO:0045190 isotype switching
GO:0071222 cellular response to lipopolysaccharide
GO:0080111 DNA demethylation
GO:0090310 negative regulation of methylation-dependent chromatin silencing
Cellular Component
GO:0000178 exosome (RNase complex)
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000111732
View Gene Order
ENSMUSG00000040627
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05340
Primary immunodeficiency pathway
hsa04672
Intestinal immune network for IgA production pathway
mmu05340
Primary immunodeficiency pathway
mmu04672
Intestinal immune network for IgA production pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL F1MV53
UniProt Splice Variant
Entrez Gene 539888
UniGene Bt.56893
RefSeq NM_001038682
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02014394
GenPept
RNA Seq Atlas 539888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca