Version 5.4
Homo sapiens Gene: PKM2
Summary
InnateDB Gene IDBG-20117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PKM2
Gene Name pyruvate kinase, muscle
Synonyms CTHBP; HEL-S-30; OIP3; PK3; PKM2; TCB; THBP1
Species Homo sapiens
Ensembl Gene ENSG00000067225
Encoded Proteins
IDBP-20119
pyruvate kinase, muscle
IDBP-20121
pyruvate kinase, muscle
IDBP-20131
pyruvate kinase, muscle
IDBP-376849
pyruvate kinase, muscle
IDBP-745946
IDBP-745618
IDBP-747788
IDBP-747137
IDBP-744862
IDBP-745726
IDBP-747626
IDBP-745538
IDBP-745573
IDBP-747644
IDBP-745864
IDBP-746725
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:72199029-72231822
Strand Reverse strand
Band q23
Transcripts
ENST00000319622 ENSP00000320171
ENST00000335181 ENSP00000334983
ENST00000389093 ENSP00000373745
ENST00000449901 ENSP00000403365
ENST00000564276
ENST00000570166
ENST00000564178 ENSP00000457198
ENST00000565154 ENSP00000455901
ENST00000563986
ENST00000562997 ENSP00000457830
ENST00000569050 ENSP00000454668
ENST00000561609 ENSP00000457253
ENST00000567087 ENSP00000456984
ENST00000565184 ENSP00000455736
ENST00000563275
ENST00000568883 ENSP00000456100
ENST00000564440
ENST00000569857 ENSP00000455584
ENST00000567118 ENSP00000456004
ENST00000562784
ENST00000568743
ENST00000566809 ENSP00000457420
ENST00000568459 ENSP00000456970
ENST00000564993
ENST00000565143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 134 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0023026 MHC class II protein complex binding
GO:0030955 potassium ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0012501 programmed cell death
GO:0016310 phosphorylation
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032294
View Gene Order
ENSBTAG00000001601
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
hsa00010
Glycolysis / Gluconeogenesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00230
Purine metabolism pathway
hsa04930
Type II diabetes mellitus pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
INOH website
Glycolysis Gluconeogenesis pathway
PID NCI
hif1_tfpathway
HIF-1-alpha transcription factor network
Cross-References
SwissProt
TrEMBL H3BN34 H3BU13
UniProt Splice Variant
Entrez Gene 5315
UniGene Hs.610382 Hs.711246 Hs.737591
RefSeq NM_001206796 NM_001206797 NM_001206798 NM_001206799 NM_002654 NM_182470 NM_182471 XM_005254443 XM_005254445 XM_006720570
HUGO HGNC:9021
OMIM 179050
CCDS CCDS32284 CCDS32285 CCDS55972 CCDS73752
HPRD 01529
IMGT
EMBL AC020779
GenPept
RNA Seq Atlas 5315

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca