InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PKM2

Summary

InnateDB Gene

IDBG-645572.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PKM2

Gene Name

pyruvate kinase isozymes M1/M2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000001601

Encoded Proteins

IDBP-698290

Pyruvate kinase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067225:
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:18965984-18992445

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000047412

ENSBTAP00000044619

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 87 interaction(s) predicted by orthology.

Predicted by orthology
Total	87 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004743	pyruvate kinase activity
GO:0005515	protein binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0023026	MHC class II protein complex binding
GO:0030955	potassium ion binding
GO:0044822	poly(A) RNA binding