InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Wnt2b

Summary

InnateDB Gene

IDBG-183421.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wnt2b

Gene Name

wingless related MMTV integration site 2b

Synonyms

Wnt13

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027840

Encoded Proteins

IDBP-183423

wingless related MMTV integration site 2b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23785285

[Homo sapiens] Secretion of WNT2B upon virus infection negatively regulates antiviral innate immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134245:
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as human carcinogenesis. This gene produces two alternatively spliced transcript variants. [provided by RefSeq, Aug 2008]
This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:104944805-104961709

Strand

Reverse strand

Band

F2.2

Transcripts

ENSMUST00000029429

ENSMUSP00000029429

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005109	frizzled binding
GO:0005515	protein binding

Biological Process

GO:0002062	chondrocyte differentiation
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0007275	multicellular organismal development
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0009887	organ morphogenesis
GO:0016055	Wnt signaling pathway
GO:0021871	forebrain regionalization
GO:0030182	neuron differentiation
GO:0060070	canonical Wnt signaling pathway
GO:0060492	lung induction
GO:0060638	mesenchymal-epithelial cell signaling
GO:0071425	hematopoietic stem cell proliferation
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway