InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Xrn1

Summary

InnateDB Gene

IDBG-191743.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Xrn1

Gene Name

5'-3' exoribonuclease 1

Synonyms

Dhm2; exo; mXrn1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032410

Encoded Proteins

IDBP-191745

5'-3' exoribonuclease 1

IDBP-788472

5'-3' exoribonuclease 1

IDBP-788473

5'-3' exoribonuclease 1

IDBP-788480

5'-3' exoribonuclease 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114127:
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:95954760-96057803

Strand

Forward strand

Band

E3.3

Transcripts

ENSMUST00000034981	ENSMUSP00000034981
ENSMUST00000185633	ENSMUSP00000140278
ENSMUST00000189106	ENSMUSP00000140004
ENSMUST00000189612
ENSMUST00000187175
ENSMUST00000190665	ENSMUSP00000139510
ENSMUST00000185759
ENSMUST00000189806
ENSMUST00000187359

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0016075	rRNA catabolic process
GO:0071028	nuclear mRNA surveillance
GO:0071044	histone mRNA catabolic process
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005622	intracellular
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0045111	intermediate filament cytoskeleton

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000114127

View Gene Order

ENSBTAG00000011524

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_24915

Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway

REACT_25064

Tristetraprolin (TTP) destabilizes mRNA pathway

REACT_20518

mRNA decay by 5' to 3' exoribonuclease pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_24994

Regulation of mRNA stability by proteins that bind AU-rich elements pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_011916 XM_006511153 XM_006511156

OMIM

CCDS

CCDS40728

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas