Version 5.4
Bos taurus Gene: XRN1
Summary
InnateDB Gene IDBG-638223.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol XRN1
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000011524
Encoded Proteins
IDBP-690322
5'-3' exoribonuclease 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114127:
SEP1 localizes to cytoplasmic foci containing a complex of mRNA-degrading enzymes. In addition to mRNA metabolism, yeast Sep1 has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly.[supplied by OMIM, Apr 2004]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:127591937-127699862
Strand Forward strand
Band
Transcripts
ENSBTAT00000015318 ENSBTAP00000015318
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000956 nuclear-transcribed mRNA catabolic process
GO:0016075 rRNA catabolic process
GO:0071028 nuclear mRNA surveillance
GO:0071044 histone mRNA catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005622 intracellular
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000114127
View Gene Order
ENSMUSG00000032410
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24915
Butyrate Response Factor 1 (BRF1) destabilizes mRNA pathway
REACT_25064
Tristetraprolin (TTP) destabilizes mRNA pathway
REACT_20518
mRNA decay by 5' to 3' exoribonuclease pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq XM_005201893
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca