Version 5.4
Bos taurus Gene: ISG20
Summary
InnateDB Gene IDBG-628915.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISG20
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000014762
Encoded Proteins
IDBP-680294
interferon stimulated exonuclease gene 20kDa
IDBP-680295
interferon stimulated exonuclease gene 20kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 15064795
[Homo sapiens] ISG20 is an IFN-induced 3'-5' exonuclease that is strongly induced by viral double stranded RNA and is activated by RELA/NFKB1.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172183:
Gene Information
Type Protein coding
Genomic Location Chromosome 21:20013719-20031094
Strand Forward strand
Band
Transcripts
ENSBTAT00000065058 ENSBTAP00000056176
ENSBTAT00000019639 ENSBTAP00000019639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity
GO:0030619 U1 snRNA binding
GO:0030620 U2 snRNA binding
GO:0034511 U3 snoRNA binding
Biological Process
GO:0000738 DNA catabolic process, exonucleolytic
GO:0006401 RNA catabolic process
GO:0009615 response to virus
GO:0045071 negative regulation of viral genome replication
GO:0051607 defense response to virus
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000172183
View Gene Order
ENSMUSG00000039236
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25162
Interferon alpha/beta signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BNM5 G3N2Q8
UniProt Splice Variant
Entrez Gene 506604
UniGene Bt.22275
RefSeq XM_002696514 XM_583075
HUGO HGNC:6130
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052106
GenPept
RNA Seq Atlas 506604

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca