Version 5.4
Homo sapiens Gene: TOPBP1
Summary
InnateDB Gene IDBG-57236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOPBP1
Gene Name topoisomerase (DNA) II binding protein 1
Synonyms TOP2BP1
Species Homo sapiens
Ensembl Gene ENSG00000163781
Encoded Proteins
IDBP-57238
topoisomerase (DNA) II binding protein 1
IDBP-480325
topoisomerase (DNA) II binding protein 1
IDBP-719614
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:133598175-133661893
Strand Reverse strand
Band q22.1
Transcripts
ENST00000260810 ENSP00000260810
ENST00000503338
ENST00000503464
ENST00000505804
ENST00000513818
ENST00000506779
ENST00000511439
ENST00000509162
ENST00000508524 ENSP00000421179
ENST00000572787 ENSP00000458790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 77 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 77 [view]
Protein-Protein 72 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042802 identical protein binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006281 DNA repair
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0000922 spindle pole
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005886 plasma membrane
GO:0016605 PML body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032555
View Gene Order
ENSBTAG00000000526
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
e2f_pathway
E2F transcription factor network
bard1pathway
BARD1 signaling events
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 11073
UniGene Hs.593379 Hs.664220
RefSeq NM_007027 XM_005247076
HUGO HGNC:17008
OMIM 607760
CCDS CCDS46919
HPRD 09678
IMGT
EMBL
GenPept
RNA Seq Atlas 11073

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca