Version 5.4
Bos taurus Gene: TOPBP1
Summary
InnateDB Gene IDBG-638950.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOPBP1
Gene Name DNA topoisomerase 2-binding protein 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000000526
Encoded Proteins
IDBP-691110
topoisomerase (DNA) II binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163781:
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:136833122-136903149
Strand Forward strand
Band
Transcripts
ENSBTAT00000000686 ENSBTAP00000000686
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006974 cellular response to DNA damage stimulus
GO:0010212 response to ionizing radiation
Cellular Component
GO:0000794 condensed nuclear chromosome
GO:0001673 male germ cell nucleus
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016605 PML body
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000163781
View Gene Order
ENSMUSG00000032555
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
e2f_pathway
E2F transcription factor network
bard1pathway
BARD1 signaling events
atr_pathway
ATR signaling pathway
Cross-References
SwissProt
TrEMBL G3X684
UniProt Splice Variant
Entrez Gene 540574
UniGene Bt.13731
RefSeq NM_001206766 XM_005201960 XM_005201961 XM_005201962
HUGO HGNC:17008
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02003073 DAAA02003074
GenPept
RNA Seq Atlas 540574

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca