Version 5.4
Mus musculus Gene: Ppa2
Summary
InnateDB Gene IDBG-194957.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppa2
Gene Name pyrophosphatase (inorganic) 2
Synonyms 1110013G13Rik; Sid6306
Species Mus musculus
Ensembl Gene ENSMUSG00000028013
Encoded Proteins
IDBP-194959
pyrophosphatase (inorganic) 2
IDBP-269019
pyrophosphatase (inorganic) 2
IDBP-400407
pyrophosphatase (inorganic) 2
IDBP-542686
pyrophosphatase (inorganic) 2
IDBP-534001
pyrophosphatase (inorganic) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138777:
The protein encoded by this gene is localized to the mitochondrion, is highly similar to members of the inorganic pyrophosphatase (PPase) family, and contains the signature sequence essential for the catalytic activity of PPase. PPases catalyze the hydrolysis of pyrophosphate to inorganic phosphate, which is important for the phosphate metabolism of cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:133310110-133378235
Strand Forward strand
Band G3
Transcripts
ENSMUST00000029644 ENSMUSP00000029644
ENSMUST00000106315 ENSMUSP00000101922
ENSMUST00000122334 ENSMUSP00000113369
ENSMUST00000153387
ENSMUST00000150386 ENSMUSP00000115462
ENSMUST00000125858 ENSMUSP00000117201
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004427 inorganic diphosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
Biological Process
GO:0006796 phosphate-containing compound metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000138777
View Gene Order
ENSBTAG00000002428
Not yet available
Pathways
NETPATH
REACTOME
REACT_233803
tRNA Aminoacylation pathway
REACT_235729
Mitochondrial tRNA aminoacylation pathway
REACT_233572
Gene Expression pathway
KEGG
mmu00190
Oxidative phosphorylation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15302
Mitochondrial tRNA aminoacylation pathway
REACT_15482
tRNA Aminoacylation pathway
REACT_71
Gene Expression pathway
KEGG
hsa00190
Oxidative phosphorylation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL D3Z636
UniProt Splice Variant
Entrez Gene 74776
UniGene
RefSeq NM_146141 XM_006502214
OMIM
CCDS CCDS17850
HPRD
IMGT
MGI ID MGI:1922026
MGI Symbol Ppa2
EMBL AC125040
GenPept
RNA Seq Atlas 74776

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca