Version 5.4
| Mus musculus Gene: Nfkb1 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-195445.7 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Symbol | Nfkb1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Gene Name | nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms | NF-kappaB; NF-kappaB1; NF-KB1; p105; p50; p50/p105 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSMUSG00000028163 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
Nfkb1 enforces specificity of cellular response to pathogens by binding to a subset of IRE sequences in IFN-inducible genes. Nfkb1 deficiency results in the inappropriate production of Ifnb in response to bacterial DNA sensed by Tlr9.
Mir126-Kdr axis is an important regulator of the innate response. Mir126 controls the survival and function of plasmacytoid dendritic cells and regulates gene expression of Tlr7, Tlr9, Nfkb1 and Kdr.
Ripk3 has a novel function in NF-kB activation, dendritic cell biology, innate inflammatory-cytokine expression, and injury-induced tissue repair.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
[Homo sapiens] NFKB1 (p50) is a distinct form of NF-kappaB that interacts with STAT3 and cooperates with STAT3 bound to GAS sites.
[Homo sapiens] NFKB1 is a subunit of the NF-kappaB transcriptional regulator complex. NF-kappaB is an inducible transcription factor that regulates the expression of numerous genes involved in immune and inflammation responses and in cellular growth control.
[Homo sapiens] NFKB1 enforces specificity of cellular response to pathogens by binding to a subset of IRE sequences in IFN-inducible genes. NFKB1 deficiency results in the inappropriate production of IFNB in response to bacterial DNA sensed by TLR9. (Demonstrated in murine model)
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| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000109320:
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 3:135584655-135691547 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Band | G3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
They are also associated with 209 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| REACTOME |
TRAF6 mediated NF-kB activation pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream TCR signaling pathway
Cellular responses to stress pathway
MyD88 cascade initiated on plasma membrane pathway
FCERI mediated NF-kB activation pathway
Cytokine Signaling in Immune system pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
Immune System pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
Cellular Senescence pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
Activation of NF-kappaB in B cells pathway
Fc epsilon receptor (FCERI) signaling pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Toll-Like Receptors Cascades pathway
Signaling by Interleukins pathway
p75NTR signals via NF-kB pathway
Interleukin-1 processing pathway
MyD88 dependent cascade initiated on endosome pathway
Cytosolic sensors of pathogen-associated DNA pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Signalling by NGF pathway
RIP-mediated NFkB activation via ZBP1 pathway
Adaptive Immune System pathway
NF-kB is activated and signals survival pathway
Activated TLR4 signalling pathway
Interleukin-1 signaling pathway
MyD88-independent cascade pathway
Regulated proteolysis of p75NTR pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
TRIF-mediated TLR3/TLR4 signaling pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
TCR signaling pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
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| KEGG |
Acute myeloid leukemia pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
Adipocytokine signaling pathway pathway
Apoptosis pathway
Prostate cancer pathway
Chronic myeloid leukemia pathway
B cell receptor signaling pathway pathway
Pancreatic cancer pathway
Chemokine signaling pathway pathway
Neurotrophin signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Leishmaniasis pathway
Amoebiasis pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Hepatitis C pathway
Chagas disease (American trypanosomiasis) pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| NETPATH |
Notch pathway
EGFR1 pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSLP pathway
TWEAK pathway
Prolactin pathway
Oncostatin_M pathway
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| REACTOME |
RIP-mediated NFkB activation via ZBP1 pathway
ZBP1(DAI) mediated induction of type I IFNs pathway
TRAF6 mediated NF-kB activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
MyD88-independent cascade pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
MyD88:Mal cascade initiated on plasma membrane pathway
Toll Like Receptor TLR1:TLR2 Cascade pathway
Toll Like Receptor TLR6:TLR2 Cascade pathway
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
MyD88 dependent cascade initiated on endosome pathway
Toll Like Receptor 9 (TLR9) Cascade pathway
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Downstream TCR signaling pathway
Interleukin-1 signaling pathway
Interleukin-1 processing pathway
Activation of NF-kappaB in B cells pathway
Regulated proteolysis of p75NTR pathway
NF-kB is activated and signals survival pathway
Transcriptional regulation of white adipocyte differentiation pathway
Cellular responses to stress pathway
Developmental Biology pathway
FCERI mediated NF-kB activation pathway
Signalling by NGF pathway
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
TCR signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
Toll Like Receptor 2 (TLR2) Cascade pathway
Toll-Like Receptors Cascades pathway
Fc epsilon receptor (FCERI) signaling pathway
p75 NTR receptor-mediated signalling pathway
p75NTR signals via NF-kB pathway
Signal Transduction pathway
Adaptive Immune System pathway
DEx/H-box helicases activate type I IFN and inflammatory cytokines production pathway
Immune System pathway
Cellular Senescence pathway
Signaling by Interleukins pathway
Activated TLR4 signalling pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Cytosolic sensors of pathogen-associated DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
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| KEGG |
Acute myeloid leukemia pathway
Epithelial cell signaling in Helicobacter pylori infection pathway
Apoptosis pathway
MAPK signaling pathway pathway
Small cell lung cancer pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Chronic myeloid leukemia pathway
Adipocytokine signaling pathway pathway
Pancreatic cancer pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
RIG-I-like receptor signaling pathway pathway
NOD-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Leishmaniasis pathway
Amoebiasis pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Shigellosis pathway
Toxoplasmosis pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-1 signaling pathway pathway
Toll-like receptor signaling pathway pathway
B cell receptor signaling pathway
TNFR1 signaling pathway pathway
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| PID NCI |
CD40/CD40L signaling
Atypical NF-kappaB pathway
Ceramide signaling pathway
LPA receptor mediated events
IL1-mediated signaling events
TNF receptor signaling pathway
IL12-mediated signaling events
Signaling events mediated by HDAC Class I
EPO signaling pathway
Glucocorticoid receptor regulatory network
BCR signaling pathway
Angiopoietin receptor Tie2-mediated signaling
IL23-mediated signaling events
Canonical NF-kappaB pathway
Fc-epsilon receptor I signaling in mast cells
IL2 signaling events mediated by PI3K
Alternative NF-kappaB pathway
amb2 Integrin signaling
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Regulation of Telomerase
Osteopontin-mediated events
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| Cross-References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_008689 XM_006501105 XM_006501107 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS17858 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI ID | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| MGI Symbol | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||||||||||||||||||