Version 5.4
Bos taurus Gene: PAN2
Summary
InnateDB Gene IDBG-636091.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PAN2
Gene Name PAB-dependent poly(A)-specific ribonuclease subunit 2
Synonyms USP52
Species Bos taurus
Ensembl Gene ENSBTAG00000004376
Encoded Proteins
IDBP-687999
PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135473:
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3\' to 5\' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:57338817-57352662
Strand Forward strand
Band
Transcripts
ENSBTAT00000061314 ENSBTAP00000053637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 291 interaction(s) predicted by orthology.
Predicted by orthology
Total 291 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000175 3'-5'-exoribonuclease activity
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0031251 PAN complex
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000135473
View Gene Order
ENSMUSG00000005682
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_20514
Deadenylation of mRNA pathway
REACT_20639
Deadenylation-dependent mRNA decay pathway
REACT_71
Gene Expression pathway
REACT_244119
Deadenylation of mRNA pathway
REACT_233572
Gene Expression pathway
REACT_235784
Deadenylation-dependent mRNA decay pathway
KEGG
hsa03018
RNA degradation pathway
mmu03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E1BML0
UniProt Splice Variant
Entrez Gene 538820
UniGene Bt.87426
RefSeq NM_001079610 XM_005206648 XM_005206649
HUGO HGNC:20074
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02013529
GenPept
RNA Seq Atlas 538820

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca