InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Aprt

Summary

InnateDB Gene

IDBG-197713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aprt

Gene Name

adenine phosphoribosyl transferase

Synonyms

C85684

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006589

Encoded Proteins

IDBP-197715

adenine phosphoribosyl transferase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198931:
Adenine phosphoribosyltransferase belongs to the purine/pyrimidine phosphoribosyltransferase family. A conserved feature of this gene is the distribution of CpG dinucleotides. This enzyme catalyzes the formation of AMP and inorganic pyrophosphate from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). It also produces adenine as a by-product of the polyamine biosynthesis pathway. A homozygous deficiency in this enzyme causes 2,8-dihydroxyadenine urolithiasis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:122574637-122576907

Strand

Reverse strand

Band

Transcripts

ENSMUST00000006764

ENSMUSP00000006764

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002055	adenine binding
GO:0003999	adenine phosphoribosyltransferase activity
GO:0016208	AMP binding

Biological Process

GO:0006166	purine ribonucleoside salvage
GO:0006168	adenine salvage
GO:0007595	lactation
GO:0007625	grooming behavior
GO:0009116	nucleoside metabolic process
GO:0032869	cellular response to insulin stimulus
GO:0044209	AMP salvage
GO:0046083	adenine metabolic process