InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: HPD

Summary

InnateDB Gene

IDBG-632894.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HPD

Gene Name

4-hydroxyphenylpyruvate dioxygenase

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004175

Encoded Proteins

IDBP-684564

4-hydroxyphenylpyruvate dioxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158104:
The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:55707870-55719927

Strand

Forward strand

Band

Transcripts

ENSBTAT00000005469

ENSBTAP00000005469

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003868	4-hydroxyphenylpyruvate dioxygenase activity
GO:0016491	oxidoreductase activity
GO:0016701	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
GO:0046872	metal ion binding
GO:0051213	dioxygenase activity

Biological Process

GO:0006559	L-phenylalanine catabolic process
GO:0006572	tyrosine catabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0055114	oxidation-reduction process