InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DDOST

Summary

InnateDB Gene

IDBG-409236.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDOST

Gene Name

dolichyl-diphosphooligosaccharide--protein glycosyltransferase

Synonyms

AGER1; CDG1R; OKSWcl45; OST; OST48; WBP1

Species

Homo sapiens

Ensembl Gene

ENSG00000244038

Encoded Proteins

IDBP-92936

dolichyl-diphosphooligosaccharide--protein glycosyltransferase

IDBP-373717

dolichyl-diphosphooligosaccharide--protein glycosyltransferase

IDBP-812705

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)

IDBP-812702

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a component of the oligosaccharyltransferase complex which catalyzes the transfer of high-mannose oligosaccharides to asparagine residues on nascent polypeptides in the lumen of the rough endoplasmic reticulum. The protein complex co-purifies with ribosomes. The product of this gene is also implicated in the processing of advanced glycation endproducts (AGEs), which form from non-enzymatic reactions between sugars and proteins or lipids and are associated with aging and hyperglycemia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:20651767-20661544

Strand

Reverse strand

Band

p36.12

Transcripts

ENST00000375048	ENSP00000364188
ENST00000415136	ENSP00000399457
ENST00000475210
ENST00000464364	ENSP00000475634
ENST00000477229
ENST00000602624	ENSP00000473655

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	51 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004576	oligosaccharyl transferase activity
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515	protein binding

Biological Process

GO:0006412	translation
GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0018279	protein N-linked glycosylation via asparagine
GO:0034097	response to cytokine
GO:0042110	T cell activation
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex