InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ptger3

Summary

InnateDB Gene

IDBG-201070.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptger3

Gene Name

prostaglandin E receptor 3 (subtype EP3)

Synonyms

EP3; Pgerep3; Ptgerep3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040016

Encoded Proteins

IDBP-201072

prostaglandin E receptor 3 (subtype EP3)

IDBP-622203

prostaglandin E receptor 3 (subtype EP3)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000050628:
The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:157566892-157644758

Strand

Forward strand

Band

Transcripts

ENSMUST00000041175	ENSMUSP00000043302
ENSMUST00000173533	ENSMUSP00000134137

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity
GO:0005515	protein binding

Biological Process

GO:0001660	fever generation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0015701	bicarbonate transport
GO:0032496	response to lipopolysaccharide
GO:0035810	positive regulation of urine volume