InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rc3h1

Summary

InnateDB Gene

IDBG-201251.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rc3h1

Gene Name

RING CCCH (C3H) domains 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040423

Encoded Proteins

IDBP-201253

RING CCCH (C3H) domains 1

IDBP-534960

RING CCCH (C3H) domains 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135870:
RC3H1, or roquin, encodes a highly conserved member of the RING type ubiquitin ligase protein family (Vinuesa et al., 2005 [PubMed 15917799]). The roquin protein is distinguished by the presence of a CCCH zinc finger found in RNA-binding proteins, and localization to cytosolic RNA granules implicated in regulating mRNA translation and stability.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:160906418-160974978

Strand

Forward strand

Band

H2.1

Transcripts

ENSMUST00000035911	ENSMUSP00000037178
ENSMUST00000161609	ENSMUSP00000124871
ENSMUST00000161708

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	5 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003729	mRNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000956	nuclear-transcribed mRNA catabolic process
GO:0001782	B cell homeostasis
GO:0002634	regulation of germinal center formation
GO:0002635	negative regulation of germinal center formation
GO:0010468	regulation of gene expression
GO:0010608	posttranscriptional regulation of gene expression
GO:0030889	negative regulation of B cell proliferation
GO:0033962	cytoplasmic mRNA processing body assembly
GO:0042098	T cell proliferation
GO:0043029	T cell homeostasis
GO:0043488	regulation of mRNA stability
GO:0045623	negative regulation of T-helper cell differentiation
GO:0046007	negative regulation of activated T cell proliferation
GO:0048535	lymph node development
GO:0048536	spleen development
GO:0050856	regulation of T cell receptor signaling pathway
GO:0061470	T follicular helper cell differentiation
GO:1901224	positive regulation of NIK/NF-kappaB signaling

Cellular Component

GO:0000932	cytoplasmic mRNA processing body
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000135870

View Gene Order

Cross-References

SwissProt

Q4VGL6

TrEMBL

H7BX02

UniProt Splice Variant

Entrez Gene

381305

UniGene

Mm.329667 Mm.415346

RefSeq

NM_001024952 XM_006496908

OMIM

CCDS

CCDS15410

HPRD

IMGT

MGI ID

MGI:2685397

MGI Symbol

Rc3h1

EMBL

AC119204 AK173335 AY948287 BC138663

GenPept

AAI38664 AAY16368 BAD32613

RNA Seq Atlas

381305