InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Psph

Summary

InnateDB Gene

IDBG-202016.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Psph

Gene Name

phosphoserine phosphatase

Synonyms

AI480570; PSP; PSPase

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029446

Encoded Proteins

IDBP-202018

phosphoserine phosphatase

IDBP-400230

phosphoserine phosphatase

IDBP-535571

phosphoserine phosphatase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146733:
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:129765558-129787252

Strand

Reverse strand

Band

G1.3

Transcripts

ENSMUST00000031399	ENSMUSP00000031399
ENSMUST00000118268	ENSMUSP00000113671
ENSMUST00000136280
ENSMUST00000136507	ENSMUSP00000116292
ENSMUST00000178244

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004647	phosphoserine phosphatase activity
GO:0005509	calcium ion binding
GO:0008253	5'-nucleotidase activity
GO:0016791	phosphatase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006563	L-serine metabolic process
GO:0006564	L-serine biosynthetic process
GO:0008152	metabolic process
GO:0009612	response to mechanical stimulus
GO:0016311	dephosphorylation
GO:0031667	response to nutrient levels
GO:0033574	response to testosterone