InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Foxn1

Summary

InnateDB Gene

IDBG-202803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Foxn1

Gene Name

forkhead box N1

Synonyms

D11Bhm185e; Fkh19; HFH-11; Hfh11; nu; nude; Whn

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002057

Encoded Proteins

IDBP-264852

forkhead box N1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is part of the forkhead family or "winged-helix" transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:78357577-78386558

Strand

Reverse strand

Band

Transcripts

ENSMUST00000108294

ENSMUSP00000103929

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0008301	DNA binding, bending
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001942	hair follicle development
GO:0002260	lymphocyte homeostasis
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007389	pattern specification process
GO:0008283	cell proliferation
GO:0008544	epidermis development
GO:0030216	keratinocyte differentiation
GO:0033081	regulation of T cell differentiation in thymus
GO:0035878	nail development
GO:0048538	thymus development
GO:0050673	epithelial cell proliferation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0005634	nucleus
GO:0005667	transcription factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000109101

View Gene Order

ENSBTAG00000013095

Not yet available

Cross-References

SwissProt

Q61575

TrEMBL

Q32MU3 Q5SYK1

UniProt Splice Variant

Entrez Gene

15218

UniGene

Mm.392151 Mm.4496

RefSeq

NM_001277290 NM_008238 XM_006532264 XM_006532265 XM_006532266 XM_006532267

OMIM

CCDS

CCDS25102

HPRD

IMGT

MGI ID

MGI:102949

MGI Symbol

Foxn1

EMBL

BC108980 BC108981 CH466556 X81593

GenPept

AAI08981 AAI08982 CAA57279 EDL15568

RNA Seq Atlas

15218