Version 5.4
Homo sapiens Gene: DHRS3
Summary
InnateDB Gene IDBG-90211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DHRS3
Gene Name dehydrogenase/reductase (SDR family) member 3
Synonyms DD83.1; RDH17; retSDR1; Rsdr1; SDR1; SDR16C1
Species Homo sapiens
Ensembl Gene ENSG00000162496
Encoded Proteins
IDBP-369869
dehydrogenase/reductase (SDR family) member 3
IDBP-808772
dehydrogenase/reductase (SDR family) member 3
IDBP-808769
dehydrogenase/reductase (SDR family) member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:12567910-12617731
Strand Reverse strand
Band p36.21
Transcripts
ENST00000430996 ENSP00000387903
ENST00000464917 ENSP00000478218
ENST00000482265
ENST00000616661 ENSP00000480439
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004745 retinol dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0052650 NADP-retinol dehydrogenase activity
Biological Process
GO:0001523 retinoid metabolic process
GO:0003151 outflow tract morphogenesis
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0030278 regulation of ossification
GO:0042572 retinol metabolic process
GO:0048387 negative regulation of retinoic acid receptor signaling pathway
GO:0055114 oxidation-reduction process
GO:0060021 palate development
GO:0060349 bone morphogenesis
GO:0060411 cardiac septum morphogenesis
Cellular Component
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066026
View Gene Order
ENSBTAG00000024493
Not yet available
Pathways
NETPATH
REACTOME
REACT_160083
The retinoid cycle in cones (daylight vision) pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00830
Retinol metabolism pathway
INOH
PID NCI
tap63pathway
Validated transcriptional targets of TAp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004753 XM_005263533
HUGO
OMIM
CCDS CCDS146
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca