InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: MASP2

Summary

InnateDB Gene

IDBG-633071.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MASP2

Gene Name

mannan-binding lectin serine protease 2 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000012808

Encoded Proteins

IDBP-684745

mannan-binding lectin serine peptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18596036

[Homo sapiens] MASP2 binds to and is activated by MBL or ficolin in response to pathogen-associated molecular patterns (PAMPs).

PMID 16189649

[Homo sapiens] MASP2, upon activation, can cleave complement component 4 (C4) and C2 to generate the C3 convertase, C4bC2b.

PMID 22792067

[Homo sapiens] MASP2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection. (Demonstrated in mice)

PMID 23785123

[Homo sapiens] MASP2 forms a complex with MASP1 to activate the complement system.

PMID 22792067

[Mus musculus] Masp2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000009724:
The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:43463199-43478362

Strand

Forward strand

Band

Transcripts

ENSBTAT00000017013

ENSBTAP00000017013

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001855	complement component C4b binding
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0016787	hydrolase activity
GO:0048306	calcium-dependent protein binding