InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MASP2

Summary

InnateDB Gene

IDBG-89176.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MASP2

Gene Name

mannan-binding lectin serine peptidase 2

Synonyms

MAP19; MASP-2; MASP1P1; sMAP

Species

Homo sapiens

Ensembl Gene

ENSG00000009724

Encoded Proteins

IDBP-227134

mannan-binding lectin serine peptidase 2

IDBP-227136

mannan-binding lectin serine peptidase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18596036

MASP2 binds to and is activated by MBL or ficolin in response to pathogen-associated molecular patterns (PAMPs).

PMID 16189649

MASP2, upon activation, can cleave complement component 4 (C4) and C2 to generate the C3 convertase, C4bC2b.

PMID 22792067

MASP2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection. (Demonstrated in mice)

PMID 23785123

MASP2 forms a complex with MASP1 to activate the complement system.

InnateDB Annotation from Orthologs

Summary

PMID 22792067

[Mus musculus] Masp2 deficient mice are defective in the lectin pathway of complement activation and are highly susceptible to pneumococcal infection.

Entrez Gene

Summary

The Ra-reactive factor (RARF) is a complement-dependent bactericidal factor that binds to the Ra and R2 polysaccharides expressed by certain enterobacteria. Alternate splicing of this gene results in two transcript variants encoding two RARF components that are involved in the mannan-binding lectin pathway of complement activation. The longer isoform is cleaved into two chains which form a heterodimer linked by a disulfide bond. The encoded proteins are members of the trypsin family of peptidases. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:11026523-11047233

Strand

Reverse strand

Band

p36.22

Transcripts

ENST00000400898	ENSP00000383691
ENST00000400897	ENSP00000383690
ENST00000478645
ENST00000480221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001855	complement component C4b binding
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0001867	complement activation, lectin pathway
GO:0006508	proteolysis
GO:0006956	complement activation
GO:0006958	complement activation, classical pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005576	extracellular region
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028979

View Gene Order

ENSBTAG00000012808

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04610

Complement and coagulation cascades pathway

hsa05150

Staphylococcus aureus infection pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.655645

RefSeq

NM_006610 NM_139208

HUGO

OMIM

CCDS

CCDS123 CCDS124

HPRD

05484

IMGT

EMBL

GenPept

RNA Seq Atlas