InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PLEKHG5

Summary

InnateDB Gene

IDBG-633823.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLEKHG5

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016728

Encoded Proteins

IDBP-685568

pleckstrin homology domain containing, family G (with RhoGef domain) member 5

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171680:
This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:47719088-47751042

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022238

ENSBTAP00000022238

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035767	endothelial cell chemotaxis
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043542	endothelial cell migration