Version 5.4
Mus musculus Gene: Smyd3
Summary
InnateDB Gene IDBG-206887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Smyd3
Gene Name SET and MYND domain containing 3
Synonyms 2410008A19Rik; Zmynd1
Species Mus musculus
Ensembl Gene ENSMUSG00000055067
Encoded Proteins
IDBP-258767
SET and MYND domain containing 3
IDBP-541073
SET and MYND domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185420:
This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:178951960-179518041
Strand Reverse strand
Band H4
Transcripts
ENSMUST00000068437
ENSMUST00000111134 ENSMUSP00000106764
ENSMUST00000128302 ENSMUSP00000117410
ENSMUST00000131684
ENSMUST00000129393
ENSMUST00000125756
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993 RNA polymerase II core binding
GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0005515 protein binding
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006334 nucleosome assembly
GO:0006469 negative regulation of protein kinase activity
GO:0014904 myotube cell development
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034968 histone lysine methylation
GO:0045184 establishment of protein localization
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071549 cellular response to dexamethasone stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000185420
View Gene Order
ENSBTAG00000033180
Not yet available
Cross-References
SwissProt Q9CWR2
TrEMBL D3YZ17
UniProt Splice Variant
Entrez Gene 69726
UniGene Mm.222338
RefSeq NM_027188 XM_006496979 XM_006496980 XM_006496981 XM_006496982
OMIM
CCDS CCDS15560
HPRD
IMGT
MGI ID MGI:1916976
MGI Symbol Smyd3
EMBL AC117756 AC120870 AC130279 AC138225 AC164397 AK010447 AK044168 AK046829 BC052431 BC061485
GenPept AAH52431 AAH61485 BAB26947 BAC31804 BAC32887
RNA Seq Atlas 69726

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca