InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Prdm16

Summary

InnateDB Gene

IDBG-207046.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prdm16

Gene Name

PR domain containing 16

Synonyms

5730557K01Rik; csp1; mel1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000039410

Encoded Proteins

IDBP-207048

PR domain containing 16

IDBP-207050

PR domain containing 16

IDBP-207052

PR domain containing 16

IDBP-270450

PR domain containing 16

IDBP-270452

PR domain containing 16

IDBP-270454

PR domain containing 16

IDBP-538096

PR domain containing 16

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000142611:
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:154316125-154636873

Strand

Reverse strand

Band

Transcripts

ENSMUST00000070313	ENSMUSP00000064546
ENSMUST00000030902	ENSMUSP00000030902
ENSMUST00000097759	ENSMUSP00000095365
ENSMUST00000105638	ENSMUSP00000101263
ENSMUST00000105637	ENSMUSP00000101262
ENSMUST00000105636	ENSMUSP00000101261
ENSMUST00000141164
ENSMUST00000145217
ENSMUST00000156069
ENSMUST00000131762
ENSMUST00000124771	ENSMUSP00000117598
ENSMUST00000135064
ENSMUST00000149605

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding
GO:0046332	SMAD binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0022008	neurogenesis
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030853	negative regulation of granulocyte differentiation
GO:0035019	somatic stem cell maintenance
GO:0043457	regulation of cellular respiration
GO:0043586	tongue development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0060021	palate development

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000142611

View Gene Order

ENSBTAG00000018965

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.257785

RefSeq

NM_001177995 NM_001291026 NM_001291029 NM_027504 XM_006539171 XM_006539172 XM_006539173 XM_006539174 XM_006539175 XM_006539176 XM_006539177 XM_006539178 XM_006539179

OMIM

CCDS

CCDS38989 CCDS51400 CCDS71530 CCDS71532

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas