Version 5.4
Mus musculus Gene: Cds2
Summary
InnateDB Gene IDBG-207331.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cds2
Gene Name CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Synonyms 5730450N06Rik; 5730460C18Rik; AI854580; D2Wsu127e
Species Mus musculus
Ensembl Gene ENSMUSG00000058793
Encoded Proteins
IDBP-207333
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
IDBP-207335
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
IDBP-260857
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
IDBP-718692
IDBP-719040
IDBP-533952
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101290:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:132263148-132312050
Strand Forward strand
Band F2
Transcripts
ENSMUST00000103181 ENSMUSP00000099470
ENSMUST00000089461 ENSMUSP00000086886
ENSMUST00000110158 ENSMUSP00000105786
ENSMUST00000147456 ENSMUSP00000135497
ENSMUST00000125060 ENSMUSP00000135710
ENSMUST00000138194 ENSMUSP00000121769
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004605 phosphatidate cytidylyltransferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0007602 phototransduction
GO:0008152 metabolic process
GO:0016024 CDP-diacylglycerol biosynthetic process
GO:0070085 glycosylation
Cellular Component
GO:0005743 mitochondrial inner membrane
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101290
View Gene Order
ENSBTAG00000006066
Not yet available
Pathways
NETPATH
REACTOME
REACT_199032
Synthesis of PG pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
mmu04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121280
Synthesis of PG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
REACT_202421
Glycerophospholipid biosynthesis pathway
REACT_206590
Synthesis of PG pathway
REACT_219933
Metabolism of lipids and lipoproteins pathway
REACT_219139
Metabolism pathway
REACT_218329
Phospholipid metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
INOH
PID NCI
Cross-References
SwissProt Q99L43
TrEMBL A2AMQ5 H3BKR7 H3BLA1 Q6PBC0
UniProt Splice Variant
Entrez Gene 110911
UniGene Mm.284503 Mm.456339 Mm.464431
RefSeq NM_001291039 NM_001291040 NM_138651 XM_006498584
OMIM
CCDS CCDS16772 CCDS71150
HPRD
IMGT
MGI ID MGI:1332236
MGI Symbol Cds2
EMBL AK036328 AK147541 AK166001 AK170888 AL807793 AY159802 BC003852 BC059776 BC069879
GenPept AAH03852 AAH59776 AAH69879 AAO17790 BAC29384 BAE27984 BAE38511 BAE42095
RNA Seq Atlas 110911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca