InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CDS2

Summary

InnateDB Gene

IDBG-639830.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDS2

Gene Name

Phosphatidate cytidylyltransferase 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000006066

Encoded Proteins

IDBP-692025

Phosphatidate cytidylyltransferase 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101290:
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:47799924-47856833

Strand

Forward strand

Band

Transcripts

ENSBTAT00000007970

ENSBTAP00000007970

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004605	phosphatidate cytidylyltransferase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016779	nucleotidyltransferase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0008654	phospholipid biosynthetic process
GO:0016024	CDP-diacylglycerol biosynthetic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane