Version 5.4
Homo sapiens Gene: CDK12
Summary
InnateDB Gene IDBG-45681.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDK12
Gene Name cyclin-dependent kinase 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167258
Encoded Proteins
IDBP-377063
cyclin-dependent kinase 12
IDBP-377066
cyclin-dependent kinase 12
IDBP-601781
cyclin-dependent kinase 12
IDBP-757945
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:39461511-39564907
Strand Forward strand
Band q12
Transcripts
ENST00000447079 ENSP00000398880
ENST00000430627 ENSP00000407720
ENST00000559663 ENSP00000453329
ENST00000559545
ENST00000558240
ENST00000585161
ENST00000581593
ENST00000584336
ENST00000584632 ENSP00000464641
ENST00000581963
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 24 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004693 cyclin-dependent protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0030332 cyclin binding
Biological Process
GO:0006397 mRNA processing
GO:0006468 protein phosphorylation
GO:0008380 RNA splicing
GO:0043405 regulation of MAP kinase activity
GO:0046777 protein autophosphorylation
GO:0051726 regulation of cell cycle
GO:0070816 phosphorylation of RNA polymerase II C-terminal domain
Cellular Component
GO:0002944 cyclin K-CDK12 complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0016607 nuclear speck
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003119
View Gene Order
ENSBTAG00000013238
Not yet available
Cross-References
SwissProt Q9NYV4
TrEMBL
UniProt Splice Variant
Entrez Gene 51755
UniGene Hs.345028 Hs.416108 Hs.601311 Hs.601797
RefSeq NM_016507 XM_005257456 NM_015083 XM_005257458
HUGO HGNC:24224
OMIM 615514
CCDS CCDS11337 CCDS45666
HPRD 10849
IMGT
EMBL AB020711 AC009283 AF227198 AK302645 BC140854 BC150265 CH471152
GenPept AAF36401 AAI40855 AAI50266 BAA74927 BAG63886 EAW60577
RNA Seq Atlas 51755

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca