Version 5.4
Mus musculus Gene: Arfgef2
Summary
InnateDB Gene IDBG-212930.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arfgef2
Gene Name ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Synonyms AI463430; AW493672; BIG2; E230011G24Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000074582
Encoded Proteins
IDBP-212932
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
IDBP-624785
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000124198:
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:166805588-166898052
Strand Forward strand
Band H3
Transcripts
ENSMUST00000099078 ENSMUSP00000096677
ENSMUST00000144847 ENSMUSP00000131572
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005488 binding
GO:0005515 protein binding
GO:0017022 myosin binding
GO:0034237 protein kinase A regulatory subunit binding
GO:0050811 GABA receptor binding
Biological Process
GO:0001881 receptor recycling
GO:0006887 exocytosis
GO:0006893 Golgi to plasma membrane transport
GO:0007032 endosome organization
GO:0010256 endomembrane system organization
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0032012 regulation of ARF protein signal transduction
GO:0032760 positive regulation of tumor necrosis factor production
GO:0035556 intracellular signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005879 axonemal microtubule
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030054 cell junction
GO:0031410 cytoplasmic vesicle
GO:0032279 asymmetric synapse
GO:0032280 symmetric synapse
GO:0043197 dendritic spine
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000124198
View Gene Order
ENSBTAG00000007120
Not yet available
Pathways
NETPATH
REACTOME
REACT_258900
Chaperonin-mediated protein folding pathway
REACT_244970
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_247926
Metabolism of proteins pathway
REACT_245534
Protein folding pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16907
Association of TriC/CCT with target proteins during biosynthesis pathway
REACT_16952
Protein folding pathway
REACT_17004
Chaperonin-mediated protein folding pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.297192 Mm.406206
RefSeq NM_001085495 XM_006500483
OMIM
CCDS CCDS38335
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca