InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARFGEF2

Summary

InnateDB Gene

IDBG-80059.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARFGEF2

Gene Name

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Synonyms

BIG2; dJ1164I10.1; PVNH2

Species

Homo sapiens

Ensembl Gene

ENSG00000124198

Encoded Proteins

IDBP-80061

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:48921890-49036693

Strand

Forward strand

Band

q13.13

Transcripts

ENST00000371917	ENSP00000360985
ENST00000493140

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005488	binding
GO:0005515	protein binding
GO:0017022	myosin binding
GO:0034237	protein kinase A regulatory subunit binding
GO:0050811	GABA receptor binding

Biological Process

GO:0001881	receptor recycling
GO:0006887	exocytosis
GO:0006893	Golgi to plasma membrane transport
GO:0007032	endosome organization
GO:0010256	endomembrane system organization
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0032012	regulation of ARF protein signal transduction
GO:0032760	positive regulation of tumor necrosis factor production
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0005879	axonemal microtubule
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle
GO:0032279	asymmetric synapse
GO:0032280	symmetric synapse
GO:0043197	dendritic spine
GO:0048471	perinuclear region of cytoplasm
GO:0055037	recycling endosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074582

View Gene Order

ENSBTAG00000007120

Not yet available

Pathways

NETPATH

REACTOME

REACT_16907

Association of TriC/CCT with target proteins during biosynthesis pathway

REACT_16952

Protein folding pathway

REACT_17004

Chaperonin-mediated protein folding pathway

REACT_17015

Metabolism of proteins pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.62578 Hs.705857 Hs.707198

RefSeq

NM_006420 XM_005260252 XM_006723683

HUGO

OMIM

CCDS

CCDS13411

HPRD

09250

IMGT

EMBL

GenPept

RNA Seq Atlas