InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNUPN

Summary

InnateDB Gene

IDBG-23512.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNUPN

Gene Name

snurportin 1

Synonyms

KPNBL; RNUT1; Snurportin1

Species

Homo sapiens

Ensembl Gene

ENSG00000169371

Encoded Proteins

IDBP-23514

snurportin 1

IDBP-745748

IDBP-745638

IDBP-746022

IDBP-745421

IDBP-745015

IDBP-745835

IDBP-745521

IDBP-746229

IDBP-745362

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5\'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:75598083-75626469

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000308588	ENSP00000309831
ENST00000567437
ENST00000564675	ENSP00000458053
ENST00000563793	ENSP00000455894
ENST00000568078	ENSP00000457562
ENST00000567134	ENSP00000456224
ENST00000568162	ENSP00000457093
ENST00000563875	ENSP00000455649
ENST00000569817	ENSP00000456260
ENST00000564644	ENSP00000454852
ENST00000564086	ENSP00000456742

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000339	RNA cap binding
GO:0005515	protein binding
GO:0008565	protein transporter activity

Biological Process

GO:0000387	spliceosomal snRNP assembly
GO:0006606	protein import into nucleus
GO:0010467	gene expression
GO:0016070	RNA metabolic process
GO:0034660	ncRNA metabolic process
GO:0061015	snRNA import into nucleus

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000055334

View Gene Order

ENSBTAG00000021293

Not yet available

Pathways

NETPATH

REACTOME

REACT_11066

snRNP Assembly pathway

REACT_11052

Metabolism of non-coding RNA pathway

REACT_71

Gene Expression pathway

KEGG

hsa03013

RNA transport pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

10073

UniGene

Hs.21577

RefSeq

NM_001042581 NM_001042588 NM_005701

HUGO

HGNC:14245

OMIM

607902

CCDS

CCDS10281

HPRD

07441

IMGT

EMBL

GenPept

RNA Seq Atlas

10073