Version 5.4
Homo sapiens Gene: PPFIBP1
Summary
InnateDB Gene IDBG-24579.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPFIBP1
Gene Name PTPRF interacting protein, binding protein 1 (liprin beta 1)
Synonyms hSGT2; hSgt2p; L2; SGT2
Species Homo sapiens
Ensembl Gene ENSG00000110841
Encoded Proteins
IDBP-24583
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-24585
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-599570
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-602958
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-596939
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-593893
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-589270
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-590840
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-583829
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-584993
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-590098
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-599913
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-591146
PTPRF interacting protein, binding protein 1 (liprin beta 1)
IDBP-813607
PTPRF interacting protein, binding protein 1 (liprin beta 1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:27523431-27695564
Strand Forward strand
Band p11.23
Transcripts
ENST00000228425 ENSP00000228425
ENST00000318304 ENSP00000314724
ENST00000538433 ENSP00000442462
ENST00000545381 ENSP00000445822
ENST00000545334 ENSP00000438036
ENST00000540114 ENSP00000444304
ENST00000541633
ENST00000537927 ENSP00000445425
ENST00000535047 ENSP00000444046
ENST00000542629 ENSP00000443442
ENST00000535575 ENSP00000437438
ENST00000542187 ENSP00000445132
ENST00000534917
ENST00000537261 ENSP00000443324
ENST00000540503
ENST00000539326 ENSP00000438174
ENST00000540256
ENST00000619325 ENSP00000479763
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008907 integrase activity
Biological Process
GO:0007155 cell adhesion
GO:0015074 DNA integration
Cellular Component
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000016487
View Gene Order
ENSBTAG00000004283
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.172445
RefSeq NM_001198915 NM_001198916 NM_003622 NM_177444 XM_005253511 XM_005253514
HUGO
OMIM
CCDS CCDS55812 CCDS55813 CCDS55814 CCDS8713
HPRD 04390
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca