Version 5.4
Bos taurus Gene: IREB2
Summary
InnateDB Gene IDBG-631031.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IREB2
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002504
Encoded Proteins
IDBP-682574
iron-responsive element binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26190773
[Mus musculus] Macrophage iron regulatory proteins Aco1 and Ireb2 are protective against Salmonella by promoting the induction of Lcn2, a host antimicrobial factor that inhibits bacterial uptake of iron-laden siderophores, and by suppressing the ferritin iron pool.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136381:
Gene Information
Type Protein coding
Genomic Location Chromosome 21:31352398-31401775
Strand Forward strand
Band
Transcripts
ENSBTAT00000003252 ENSBTAP00000003252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030350 iron-responsive element binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006417 regulation of translation
GO:0006782 protoporphyrinogen IX biosynthetic process
GO:0006879 cellular iron ion homeostasis
GO:0008152 metabolic process
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0030316 osteoclast differentiation
GO:0034101 erythrocyte homeostasis
GO:0050892 intestinal absorption
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000136381
View Gene Order
ENSMUSG00000032293
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt
TrEMBL E1BNR2
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq
HUGO HGNC:6115
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02052431 DAAA02052432 DAAA02052433
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca