Homo sapiens Gene: ADAMTS10

Summary
InnateDB Gene IDBG-25135.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ADAMTS10
Gene Name ADAM metallopeptidase with thrombospondin type 1 motif, 10
Synonyms ADAM-TS10; WMS; WMS1
Species Homo sapiens
Ensembl Gene ENSG00000142303
Encoded Proteins
IDBP-25137 ADAM metallopeptidase with thrombospondin type 1 motif, 10
IDBP-764494
IDBP-765744
IDBP-765253
IDBP-760340
IDBP-763841
Entrez Gene
Summary This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 8645126-8675620
Strand Reverse strand
Band p13.2
Transcripts
ENST00000270328  ENSP00000270328
ENST00000601163 
ENST00000593534 
ENST00000596236 
ENST00000596466 
ENST00000601872 
ENST00000596911 
ENST00000595838  ENSP00000470501
ENST00000596851  ENSP00000469559
ENST00000597188  ENSP00000471851
ENST00000593913  ENSP00000469901
ENST00000593826  ENSP00000469516
ENST00000596709 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein‑Protein  7
[view]
Protein‑DNA 2
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003674 molecular_function
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0001527 microfibril
GO:0005575 cellular_component
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000024299 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000014207 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9H324 
TrEMBL
UniProt Splice Variant
Entrez Gene 81794 
UniGene Hs.657508
RefSeq
HUGO 13201 
OMIM 608990
CCDS CCDS12206 
HPRD 07470
IMGT
EMBL AC092315 AC130469 AF163762
GenPept AAG35563 
ImmGen ADAMTS10 (murine) 
RNA Seq Atlas 81794