Version 5.4
Mus musculus Gene: Slc8a3
Summary
InnateDB Gene IDBG-260476.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc8a3
Gene Name solute carrier family 8 (sodium/calcium exchanger), member 3
Synonyms AW742262; Ncx3
Species Mus musculus
Ensembl Gene ENSMUSG00000079055
Encoded Proteins
IDBP-154262
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-154264
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-788899
solute carrier family 8 (sodium/calcium exchanger), member 3
IDBP-788900
solute carrier family 8 (sodium/calcium exchanger), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100678:
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Jul 2008]
This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:81197915-81333180
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000085238 ENSMUSP00000082334
ENSMUST00000064594 ENSMUSP00000063258
ENSMUST00000182208 ENSMUSP00000138735
ENSMUST00000182366 ENSMUSP00000138803
ENSMUST00000183102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005432 calcium:sodium antiporter activity
GO:0015368 calcium:cation antiporter activity
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006814 sodium ion transport
GO:0006816 calcium ion transport
GO:0007154 cell communication
GO:0021537 telencephalon development
GO:0030001 metal ion transport
GO:0035725 sodium ion transmembrane transport
GO:0055085 transmembrane transport
GO:0060402 calcium ion transport into cytosol
GO:0070588 calcium ion transmembrane transport
GO:0071320 cellular response to cAMP
GO:1990034 calcium ion export from cell
GO:1990035 calcium ion import into cell
Cellular Component
GO:0005739 mitochondrion
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0042383 sarcolemma
GO:0042995 cell projection
GO:0043025 neuronal cell body
GO:0043197 dendritic spine
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000100678
View Gene Order
ENSBTAG00000027080
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04020
Calcium signaling pathway pathway
mmu04974
Protein digestion and absorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_23765
Reduction of cytosolic Ca++ levels pathway
REACT_23876
Platelet homeostasis pathway
REACT_19320
Sodium/Calcium exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_23905
Platelet calcium homeostasis pathway
REACT_19118
SLC-mediated transmembrane transport pathway
REACT_604
Hemostasis pathway
KEGG
hsa04020
Calcium signaling pathway pathway
hsa04974
Protein digestion and absorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001167920 NM_080440 XM_006515411 XM_006515412 XM_006515414
OMIM
CCDS CCDS36485 CCDS49103
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca