Version 5.4
Bos taurus Gene: PON1
Summary
InnateDB Gene IDBG-629289.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PON1
Gene Name serum paraoxonase/arylesterase 1 precursor
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000015654
Encoded Proteins
IDBP-680696
serum paraoxonase/arylesterase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005421:
The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:12389567-12423459
Strand Reverse strand
Band
Transcripts
ENSBTAT00000020790 ENSBTAP00000020790
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004063 aryldialkylphosphatase activity
GO:0004064 arylesterase activity
GO:0005509 calcium ion binding
GO:0005543 phospholipid binding
GO:0016844 strictosidine synthase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0009058 biosynthetic process
GO:0009636 response to toxic substance
GO:0010875 positive regulation of cholesterol efflux
GO:0019439 aromatic compound catabolic process
GO:0032411 positive regulation of transporter activity
GO:0046395 carboxylic acid catabolic process
GO:0046434 organophosphate catabolic process
GO:0046470 phosphatidylcholine metabolic process
GO:0051099 positive regulation of binding
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0034366 spherical high-density lipoprotein particle
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000005421
View Gene Order
ENSMUSG00000002588
View Gene Order
Cross-References
SwissProt
TrEMBL Q2KIW1
UniProt Splice Variant
Entrez Gene 523798
UniGene Bt.19690
RefSeq NM_001046269
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112488 DAAA02009788
GenPept AAI12489
RNA Seq Atlas 523798

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca