Version 5.4
| Homo sapiens Gene: B3GALT4 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-304157.4 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | B3GALT4 | ||||||||||||||||||
| Gene Name | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 | ||||||||||||||||||
| Synonyms | BETA3GALT4; GALT2; GALT4 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000235863 | ||||||||||||||||||
| Encoded Proteins |
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:33277132-33284832 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | p21.32 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME | |||||||||||||||||||
| KEGG |
Glycosphingolipid biosynthesis pathway
Other types of O-glycan biosynthesis pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | O96024 | ||||||||||||||||||
| TrEMBL | Q5STJ7 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 8705 | ||||||||||||||||||
| UniGene | Hs.534375 | ||||||||||||||||||
| RefSeq | NM_003782 | ||||||||||||||||||
| HUGO | HGNC:919 | ||||||||||||||||||
| OMIM | 603095 | ||||||||||||||||||
| CCDS | CCDS34425 | ||||||||||||||||||
| HPRD | 04370 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AB026730 AK315647 AL031228 BC032574 CH471081 CR457093 FJ525877 Y15061 | ||||||||||||||||||
| GenPept | AAH32574 ACN81315 BAA88988 BAG38014 CAA20230 CAA75345 CAG33374 EAX03700 | ||||||||||||||||||
| RNA Seq Atlas | 8705 | ||||||||||||||||||