Version 5.4
Homo sapiens Gene: DPYSL5
Summary
InnateDB Gene IDBG-36183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPYSL5
Gene Name dihydropyrimidinase-like 5
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000157851
Encoded Proteins
IDBP-36189
dihydropyrimidinase-like 5
IDBP-294659
dihydropyrimidinase-like 5
IDBP-368297
dihydropyrimidinase-like 5
IDBP-368345
dihydropyrimidinase-like 5
IDBP-368349
dihydropyrimidinase-like 5
IDBP-808134
dihydropyrimidinase-like 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the CRMP (collapsing response mediator protein) family thought to be involved in neural development. Antibodies to the encoded protein were found in some patients with neurologic symptoms who had paraneoplastic syndrome. A pseudogene of this gene is found on chromosome 11. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:26847747-26950351
Strand Forward strand
Band p23.3
Transcripts
ENST00000288699 ENSP00000288699
ENST00000401478 ENSP00000385549
ENST00000450961 ENSP00000407174
ENST00000431402 ENSP00000399581
ENST00000434719 ENSP00000413075
ENST00000484882
ENST00000614712 ENSP00000481305
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Biological Process
GO:0006208 pyrimidine nucleobase catabolic process
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029168
View Gene Order
ENSBTAG00000018576
Not yet available
Pathways
NETPATH
REACTOME
REACT_19199
CRMPs in Sema3A signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.299315
RefSeq NM_001253723 NM_001253724 NM_020134
HUGO
OMIM
CCDS CCDS1730
HPRD 10522
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca