InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SUZ12

Summary

InnateDB Gene

IDBG-631171.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUZ12

Gene Name

polycomb protein SUZ12

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000018752

Encoded Proteins

IDBP-682764

suppressor of zeste 12 homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000178691:
This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:18507782-18544957

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000024971

ENSBTAP00000024971

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042054	histone methyltransferase activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0008284	positive regulation of cell proliferation
GO:0016571	histone methylation
GO:0016574	histone ubiquitination
GO:0045596	negative regulation of cell differentiation