Version 5.4
Homo sapiens Gene: CELF1
Summary
InnateDB Gene IDBG-43515.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CELF1
Gene Name CUGBP, Elav-like family member 1
Synonyms BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR
Species Homo sapiens
Ensembl Gene ENSG00000149187
Encoded Proteins
IDBP-43517
CUGBP, Elav-like family member 1
IDBP-43519
CUGBP, Elav-like family member 1
IDBP-43521
CUGBP, Elav-like family member 1
IDBP-239849
CUGBP, Elav-like family member 1
IDBP-239851
CUGBP, Elav-like family member 1
IDBP-586298
CUGBP, Elav-like family member 1
IDBP-595552
CUGBP, Elav-like family member 1
IDBP-585730
CUGBP, Elav-like family member 1
IDBP-600588
CUGBP, Elav-like family member 1
IDBP-600900
CUGBP, Elav-like family member 1
IDBP-597319
CUGBP, Elav-like family member 1
IDBP-584955
CUGBP, Elav-like family member 1
IDBP-595102
CUGBP, Elav-like family member 1
IDBP-586288
CUGBP, Elav-like family member 1
IDBP-589788
CUGBP, Elav-like family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47465944-47565569
Strand Reverse strand
Band p11.2
Transcripts
ENST00000310513 ENSP00000308386
ENST00000358597 ENSP00000351409
ENST00000361904 ENSP00000354639
ENST00000366360
ENST00000395292 ENSP00000378706
ENST00000395290 ENSP00000378705
ENST00000422993
ENST00000539455
ENST00000531165 ENSP00000436864
ENST00000532048 ENSP00000435926
ENST00000524648
ENST00000539254
ENST00000534614
ENST00000532146
ENST00000530151 ENSP00000433986
ENST00000528434 ENSP00000435320
ENST00000525841 ENSP00000436191
ENST00000543178 ENSP00000444825
ENST00000535982 ENSP00000438044
ENST00000526419 ENSP00000435423
ENST00000528538 ENSP00000442415
ENST00000526277 ENSP00000438862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0042835 BRE binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0007281 germ cell development
GO:0007286 spermatid development
GO:0009790 embryo development
GO:0016246 RNA interference
GO:0017148 negative regulation of translation
GO:0040018 positive regulation of multicellular organism growth
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005506
View Gene Order
ENSBTAG00000002520
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.595333 Hs.614450 Hs.709008 Hs.715087
RefSeq NM_001025596 NM_001172639 NM_001172640 NM_006560 NM_198700 XM_005252756 XM_006718122 XM_006718126 XM_006718127 XM_006718128 XM_006718129 XM_006718130 XM_006718131
HUGO
OMIM
CCDS CCDS31482 CCDS53622 CCDS53623 CCDS7938 CCDS7939
HPRD 03046
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca