Homo sapiens Gene: CELF1

Summary
InnateDB Gene IDBG-43515.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol CELF1
Gene Name CUGBP, Elav-like family member 1
Synonyms BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR
Species Homo sapiens
Ensembl Gene ENSG00000149187
Encoded Proteins
IDBP-43517 CUGBP, Elav-like family member 1
IDBP-43519 CUGBP, Elav-like family member 1
IDBP-43521 CUGBP, Elav-like family member 1
IDBP-239849 CUGBP, Elav-like family member 1
IDBP-239851 CUGBP, Elav-like family member 1
IDBP-586298 CUGBP, Elav-like family member 1
IDBP-595552 CUGBP, Elav-like family member 1
IDBP-585730 CUGBP, Elav-like family member 1
IDBP-600588 CUGBP, Elav-like family member 1
IDBP-600900 CUGBP, Elav-like family member 1
IDBP-597319 CUGBP, Elav-like family member 1
IDBP-584955 CUGBP, Elav-like family member 1
IDBP-595102 CUGBP, Elav-like family member 1
IDBP-586288 CUGBP, Elav-like family member 1
IDBP-589788 CUGBP, Elav-like family member 1
Entrez Gene
Summary Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11: 47487496-47587121
Strand Reverse strand
Band p11.2
Transcripts
ENST00000310513  ENSP00000308386
ENST00000358597  ENSP00000351409
ENST00000361904  ENSP00000354639
ENST00000366360 
ENST00000395292  ENSP00000378706
ENST00000395290  ENSP00000378705
ENST00000422993 
ENST00000539455 
ENST00000531165  ENSP00000436864
ENST00000532048  ENSP00000435926
ENST00000524648 
ENST00000539254 
ENST00000534614 
ENST00000532146 
ENST00000530151  ENSP00000433986
ENST00000528434  ENSP00000435320
ENST00000525841  ENSP00000436191
ENST00000543178  ENSP00000444825
ENST00000535982  ENSP00000438044
ENST00000526419  ENSP00000435423
ENST00000528538  ENSP00000442415
ENST00000526277  ENSP00000438862
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein‑Protein  14
[view]
Protein‑DNA 0
Protein‑RNA 2
[view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0000166 nucleotide binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0042835 BRE binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0007281 germ cell development
GO:0007286 spermatid development
GO:0009790 embryo development
GO:0016246 RNA interference
GO:0040018 positive regulation of multicellular organism growth
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000005506 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000002520 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q92879 
TrEMBL B4E2U5 E9PKA1 E9PKU1 E9PQK4 E9PSH0 F5H0D8 F5H3J7 F5H4Y5 F8W940 G5EA30
UniProt Splice Variant
Entrez Gene 10658 
UniGene Hs.595333 Hs.614450 Hs.709008 Hs.715087
RefSeq NM_001025596  NM_001172639  NM_001172640  NM_006560 
HUGO 2549 
OMIM 601074
CCDS CCDS31482  CCDS53622  CCDS53623  CCDS7938  CCDS7939 
HPRD 03046
IMGT
EMBL AB210019 AC090559 AF248648 AF267533 AF267534 AJ007988 AK304430 BC031079 CH471064 U63289
GenPept AAC50895  AAF78955  AAF78956  AAF86230  AAH31079  BAE06101  BAG65257  CAC20566  EAW67908  EAW67909  EAW67912 
ImmGen CELF1 (murine) 
RNA Seq Atlas 10658