Homo sapiens Gene: CELF1
Summary
InnateDB Gene IDBG-43515.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol CELF1
Gene Name CUGBP, Elav-like family member 1
Synonyms BRUNOL2; CUG-BP; CUGBP; CUGBP1; EDEN-BP; hNab50; NAB50; NAPOR;
Species Homo sapiens
Ensembl Gene ENSG00000149187
Encoded Proteins
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
CUGBP, Elav-like family member 1
Protein Structure
Entrez Gene
Summary Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:47487496-47587121
Strand Reverse strand
Band p11.2
Transcripts
ENST00000310513 ENSP00000308386
ENST00000358597 ENSP00000351409
ENST00000361904 ENSP00000354639
ENST00000366360
ENST00000395292 ENSP00000378706
ENST00000395290 ENSP00000378705
ENST00000422993
ENST00000539455
ENST00000531165 ENSP00000436864
ENST00000532048 ENSP00000435926
ENST00000524648
ENST00000539254
ENST00000534614
ENST00000532146
ENST00000530151 ENSP00000433986
ENST00000528434 ENSP00000435320
ENST00000525841 ENSP00000436191
ENST00000543178 ENSP00000444825
ENST00000535982 ENSP00000438044
ENST00000526419 ENSP00000435423
ENST00000528538 ENSP00000442415
ENST00000526277 ENSP00000438862
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 2 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0000900 translation repressor activity, nucleic acid binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0031369 translation initiation factor binding
GO:0042835 BRE binding
Biological Process
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0007281 germ cell development
GO:0007286 spermatid development
GO:0009790 embryo development
GO:0016246 RNA interference
GO:0040018 positive regulation of multicellular organism growth
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0030529 ribonucleoprotein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Cross-References
SwissProt Q92879
TrEMBL B4E2U5 E9PKA1 E9PKU1 E9PQK4 E9PSH0 F5H0D8 F5H3J7 F5H4Y5 F8W940 G5EA30
UniProt Splice Variant
Entrez Gene 10658
UniGene Hs.595333 Hs.614450 Hs.709008 Hs.715087
RefSeq NM_001025596 NM_001172639 NM_001172640 NM_006560
HUGO 2549
OMIM 601074
CCDS CCDS31482 CCDS53622 CCDS53623 CCDS7938 CCDS7939
HPRD 03046
IMGT
EMBL AB210019 AC090559 AF248648 AF267533 AF267534 AJ007988 AK304430 BC031079 CH471064 U63289
GenPept AAC50895 AAF78955 AAF78956 AAF86230 AAH31079 BAE06101 BAG65257 CAC20566 EAW67908 EAW67909 EAW67912
ImmGen CELF1 (murine)
RNA Seq Atlas 10658