Version 5.4
Homo sapiens Gene: SMARCA2
Summary
InnateDB Gene IDBG-44200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMARCA2
Gene Name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Synonyms BAF190; BRM; hBRM; hSNF2a; NCBRS; SNF2; SNF2L2; SNF2LA; Sth1p; SWI2
Species Homo sapiens
Ensembl Gene ENSG00000080503
Encoded Proteins
IDBP-28598
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44202
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44204
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44206
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44208
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44210
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44212
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44214
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-44216
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361564
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361568
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361570
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361592
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361600
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361602
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
IDBP-361609
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19144648
A member of the SWI/SNF family of proteins and is essential for the multiple changes in gene expression that occur during differentiation
PMID 19342595
Required for maintaining expression of several smooth muscle-specific genes
Entrez Gene
Summary The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:2015219-2193624
Strand Forward strand
Band p24.3
Transcripts
ENST00000324954 ENSP00000324770
ENST00000349721 ENSP00000265773
ENST00000357248 ENSP00000349788
ENST00000382203 ENSP00000371638
ENST00000382194 ENSP00000371629
ENST00000302401 ENSP00000305411
ENST00000382186 ENSP00000371621
ENST00000382185 ENSP00000371620
ENST00000382183 ENSP00000371618
ENST00000450198 ENSP00000392081
ENST00000457226 ENSP00000415218
ENST00000439732 ENSP00000409398
ENST00000452193 ENSP00000401096
ENST00000423555 ENSP00000413057
ENST00000417599 ENSP00000387486
ENST00000416751 ENSP00000412242
ENST00000491574
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 143 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 143 [view]
Protein-Protein 139 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001105 RNA polymerase II transcription coactivator activity
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008094 DNA-dependent ATPase activity
GO:0016817 hydrolase activity, acting on acid anhydrides
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042393 histone binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006200 ATP catabolic process
GO:0006338 chromatin remodeling
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0008152 metabolic process
GO:0008285 negative regulation of cell proliferation
GO:0030308 negative regulation of cell growth
GO:0035887 aortic smooth muscle cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016514 SWI/SNF complex
GO:0043231 intracellular membrane-bounded organelle
GO:0045111 intermediate filament cytoskeleton
GO:0071564 npBAF complex
GO:0071565 nBAF complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024921
View Gene Order
ENSBTAG00000007494
Not yet available
Pathways
NETPATH
REACTOME
REACT_172623
Chromatin organization pathway
REACT_228108
RMTs methylate histone arginines pathway
REACT_172633
Chromatin modifying enzymes pathway
KEGG
INOH
PID NCI
cmyb_pathway
C-MYB transcription factor network
e2f_pathway
E2F transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.298990
RefSeq NM_001289396 NM_001289397 NM_001289398 NM_001289399 NM_001289400 NM_003070 NM_139045
HUGO
OMIM
CCDS CCDS34977 CCDS34978 CCDS75807 CCDS75808
HPRD 02483
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca