InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SMARCA2

Summary

InnateDB Gene

IDBG-631631.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMARCA2

Gene Name

probable global transcription activator SNF2L2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000007494

Encoded Proteins

IDBP-683205

probable global transcription activator SNF2L2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 19144648

[Homo sapiens] A member of the SWI/SNF family of proteins and is essential for the multiple changes in gene expression that occur during differentiation

PMID 19342595

[Homo sapiens] Required for maintaining expression of several smooth muscle-specific genes

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000080503:
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:42652775-42830159

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000035681

ENSBTAP00000035551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 100 interaction(s) predicted by orthology.

Predicted by orthology
Total	100 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016817	hydrolase activity, acting on acid anhydrides
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0042393	histone binding
GO:0044212	transcription regulatory region DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0008152	metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0030308	negative regulation of cell growth
GO:0035887	aortic smooth muscle cell differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0016514	SWI/SNF complex
GO:0043231	intracellular membrane-bounded organelle
GO:0045111	intermediate filament cytoskeleton
GO:0071564	npBAF complex
GO:0071565	nBAF complex