Homo sapiens Gene: TASP1
Summary
InnateDB Gene IDBG-54630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TASP1
Gene Name taspase, threonine aspartase, 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000089123
Encoded Proteins
taspase, threonine aspartase, 1
taspase, threonine aspartase, 1
taspase, threonine aspartase, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:13389392-13638940
Strand Reverse strand
Band p12.1
Transcripts
ENST00000337743 ENSP00000338624
ENST00000455532 ENSP00000400580
ENST00000434275 ENSP00000387574
ENST00000480436
ENST00000465381
ENST00000476108
ENST00000483898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006508 proteolysis
GO:0008152 metabolic process
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 55617
UniGene Hs.348297
RefSeq NM_017714 XM_006723590
HUGO HGNC:15859
OMIM 608270
CCDS CCDS13116
HPRD 07460
IMGT
EMBL
GenPept
RNA Seq Atlas 55617