Homo sapiens Gene: NFE2L1

Summary
InnateDB Gene IDBG-56544.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol NFE2L1
Gene Name nuclear factor (erythroid-derived 2)-like 1
Synonyms LCR-F1; NRF1; TCF11
Species Homo sapiens
Ensembl Gene ENSG00000082641
Encoded Proteins
IDBP-56546 nuclear factor (erythroid-derived 2)-like 1
IDBP-56548 nuclear factor (erythroid-derived 2)-like 1
IDBP-56550 nuclear factor (erythroid-derived 2)-like 1
IDBP-591452 nuclear factor (erythroid-derived 2)-like 1
IDBP-759422
IDBP-761687
IDBP-758430
IDBP-762480
IDBP-760000
IDBP-764805
IDBP-758885
IDBP-764692
IDBP-764428
IDBP-762907
IDBP-758323
IDBP-760708
IDBP-760676
IDBP-758855
IDBP-759878
Entrez Gene
Summary This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 46125691-46138849
Strand Forward strand
Band q21.32
Transcripts
ENST00000357480  ENSP00000350072
ENST00000362042  ENSP00000354855
ENST00000361665  ENSP00000355190
ENST00000536222  ENSP00000445811
ENST00000583060 
ENST00000585062  ENSP00000463960
ENST00000584634  ENSP00000462971
ENST00000583210  ENSP00000464018
ENST00000582574 
ENST00000581441  ENSP00000462253
ENST00000581319  ENSP00000461971
ENST00000580037  ENSP00000463744
ENST00000580050  ENSP00000464203
ENST00000577411  ENSP00000462610
ENST00000585299 
ENST00000579889  ENSP00000462003
ENST00000583378  ENSP00000463291
ENST00000579481 
ENST00000577431  ENSP00000463836
ENST00000584137  ENSP00000463657
ENST00000582155  ENSP00000464446
ENST00000585291  ENSP00000461960
ENST00000579537  ENSP00000462444
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein‑Protein  20
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of transcription, DNA-dependent
GO:0006366 transcription from RNA polymerase II promoter
GO:0006783 heme biosynthetic process
GO:0006954 inflammatory response
GO:0009653 anatomical structure morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000038615 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013653 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q14494 
TrEMBL B4DYE1 F5H1B7 J3KRF3 J3KSE0 J3KSR3 J3QKY3 J3QLQ1 J3QQH8 J3QQQ1 J3QQY8 J3QR31 J3QRG7 J9JIE5 Q8NF22
UniProt Splice Variant
Entrez Gene 4779 
UniGene Hs.514284 Hs.595173 Hs.623028 Hs.666213 Hs.740157
RefSeq NM_003204 
HUGO 7781 
OMIM 163260
CCDS CCDS11524 
HPRD 01223
IMGT
EMBL AC004477 AK090459 AK302387 BC010623 CH471109 L24123 U08853 X77366
GenPept AAA20466  AAH10623  BAC03440  BAG63703  CAA54555  EAW94762  EAW94763  EAW94764  EAW94765  EAW94766  EAW94767 
ImmGen NFE2L1 (murine) 
RNA Seq Atlas 4779