Version 5.4
Homo sapiens Gene: NFE2L1
Summary
InnateDB Gene IDBG-56544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFE2L1
Gene Name nuclear factor (erythroid-derived 2)-like 1
Synonyms LCR-F1; NRF1; TCF11
Species Homo sapiens
Ensembl Gene ENSG00000082641
Encoded Proteins
IDBP-56546
nuclear factor (erythroid-derived 2)-like 1
IDBP-56548
nuclear factor (erythroid-derived 2)-like 1
IDBP-56550
nuclear factor (erythroid-derived 2)-like 1
IDBP-591452
nuclear factor (erythroid-derived 2)-like 1
IDBP-759422
IDBP-761687
IDBP-758430
IDBP-762480
IDBP-760000
IDBP-764805
IDBP-758885
IDBP-764692
IDBP-764428
IDBP-762907
IDBP-758323
IDBP-760708
IDBP-760676
IDBP-758855
IDBP-759878
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48048329-48061487
Strand Forward strand
Band q21.32
Transcripts
ENST00000357480 ENSP00000350072
ENST00000362042 ENSP00000354855
ENST00000361665 ENSP00000355190
ENST00000536222 ENSP00000445811
ENST00000583060
ENST00000585062 ENSP00000463960
ENST00000584634 ENSP00000462971
ENST00000583210 ENSP00000464018
ENST00000582574
ENST00000581441 ENSP00000462253
ENST00000581319 ENSP00000461971
ENST00000580037 ENSP00000463744
ENST00000580050 ENSP00000464203
ENST00000577411 ENSP00000462610
ENST00000585299
ENST00000579889 ENSP00000462003
ENST00000583378 ENSP00000463291
ENST00000579481
ENST00000577431 ENSP00000463836
ENST00000584137 ENSP00000463657
ENST00000582155 ENSP00000464446
ENST00000585291 ENSP00000461960
ENST00000579537 ENSP00000462444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006783 heme biosynthetic process
GO:0006954 inflammatory response
GO:0009653 anatomical structure morphogenesis
GO:0030218 erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038615
View Gene Order
ENSBTAG00000013653
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514284 Hs.595173 Hs.623028 Hs.666213 Hs.740157
RefSeq NM_003204 XM_005257410 XM_005257411 XM_005257412 XM_005257413
HUGO
OMIM
CCDS CCDS11524
HPRD 01223
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca