Homo sapiens Gene: NFE2L1
Summary
InnateDB Gene IDBG-56544.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NFE2L1
Gene Name nuclear factor (erythroid-derived 2)-like 1
Synonyms LCR-F1; NRF1; TCF11;
Species Homo sapiens
Ensembl Gene ENSG00000082641
Encoded Proteins
nuclear factor (erythroid-derived 2)-like 1
nuclear factor (erythroid-derived 2)-like 1
nuclear factor (erythroid-derived 2)-like 1
nuclear factor (erythroid-derived 2)-like 1
Protein Structure
Entrez Gene
Summary This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:48048329-48061487
Strand Forward strand
Band q21.32
Transcripts
ENST00000357480 ENSP00000350072
ENST00000362042 ENSP00000354855
ENST00000361665 ENSP00000355190
ENST00000536222 ENSP00000445811
ENST00000583060
ENST00000585062 ENSP00000463960
ENST00000584634 ENSP00000462971
ENST00000583210 ENSP00000464018
ENST00000582574
ENST00000581441 ENSP00000462253
ENST00000581319 ENSP00000461971
ENST00000580037 ENSP00000463744
ENST00000580050 ENSP00000464203
ENST00000577411 ENSP00000462610
ENST00000585299
ENST00000579889 ENSP00000462003
ENST00000583378 ENSP00000463291
ENST00000579481
ENST00000577431 ENSP00000463836
ENST00000584137 ENSP00000463657
ENST00000582155 ENSP00000464446
ENST00000585291 ENSP00000461960
ENST00000579537 ENSP00000462444
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 23 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006783 heme biosynthetic process
GO:0006954 inflammatory response
GO:0009653 anatomical structure morphogenesis
GO:0030218 erythrocyte differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q14494
TrEMBL B4DYE1 F5H1B7 J3KRF3 J3KSE0 J3KSR3 J3QKY3 J3QLQ1 J3QQH8 J3QQQ1 J3QQY8 J3QR31 J3QRG7 J9JIE5 Q8NF22
UniProt Splice Variant
Entrez Gene 4779
UniGene Hs.514284 Hs.595173 Hs.623028 Hs.666213 Hs.740157
RefSeq NM_003204 XM_005257410 XM_005257411 XM_005257412 XM_005257413
HUGO HGNC:7781
OMIM 163260
CCDS CCDS11524
HPRD 01223
IMGT
EMBL AC004477 AK090459 AK302387 BC010623 CH471109 L24123 U08853 X77366
GenPept AAA20466 AAH10623 BAC03440 BAG63703 CAA54555 EAW94762 EAW94763 EAW94764 EAW94765 EAW94766 EAW94767
ImmGen NFE2L1 (murine)
RNA Seq Atlas 4779